Version 5.4
Homo sapiens Protein: IFNG
Summary
InnateDB Protein IDBP-45918.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNG
Protein Name interferon, gamma
Synonyms IFG; IFI;
Species Homo sapiens
Ensembl Protein ENSP00000229135
InnateDB Gene IDBG-45916 (IFNG)
Protein Structure
UniProt Annotation
Function Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Subcellular Localization Secreted.
Disease Associations Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Tissue Specificity Released primarily from activated T lymphocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 9 [view]
Protein-DNA 19 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005133 interferon-gamma receptor binding
GO:0005515 protein binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001781 neutrophil apoptotic process
GO:0002026 regulation of the force of heart contraction
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002250 adaptive immune response
GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006925 inflammatory cell apoptotic process
GO:0006928 cellular component movement
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007050 cell cycle arrest
GO:0007166 cell surface receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0019882 antigen processing and presentation
GO:0030593 neutrophil chemotaxis
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031642 negative regulation of myelination
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0032700 negative regulation of interleukin-17 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0042102 positive regulation of T cell proliferation
GO:0042493 response to drug
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0044130 negative regulation of growth of symbiont in host
GO:0044146 negative regulation of growth of symbiont involved in interaction with host
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045666 positive regulation of neuron differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050776 regulation of immune response
GO:0050796 regulation of insulin secretion
GO:0050954 sensory perception of mechanical stimulus
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of other organism
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060550 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process
GO:0060557 positive regulation of vitamin D biosynthetic process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0071222 cellular response to lipopolysaccharide
GO:0071351 cellular response to interleukin-18
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0097191 extrinsic apoptotic signaling pathway
GO:0098908 regulation of neuronal action potential
GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000345 regulation of hepatocyte proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR002069 Interferon gamma
IPR009079 Four-helical cytokine-like, core
PFAM PF00714
PRINTS
PIRSF PIRSF001936
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01579
PhosphoSite PhosphoSite-P01579
TrEMBL A1Z2M2
UniProt Splice Variant
Entrez Gene 3458
UniGene Hs.856
RefSeq NP_000610
HUGO HGNC:5438
OMIM 147570
CCDS CCDS8980
HPRD 00957
IMGT
EMBL AB451324 AB451453 AF375790 AY255837 BC070256 CH471054 EF173872 J00219 V00543 X01992 X13274
GenPept AAB59534 AAH70256 AAK53058 AAP20098 ABM53145 BAG70138 BAG70267 CAA23804 CAA26022 CAA31639 EAW97180

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca