Homo sapiens Gene: ERBB2
Summary
InnateDB Gene IDBG-46068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERBB2
Gene Name v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Synonyms CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1;
Species Homo sapiens
Ensembl Gene ENSG00000141736
Encoded Proteins
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39687914-39730426
Strand Forward strand
Band q12
Transcripts
ENST00000269571 ENSP00000269571
ENST00000406381 ENSP00000385185
ENST00000445658 ENSP00000404047
ENST00000541774 ENSP00000446466
ENST00000578502 ENSP00000464420
ENST00000578630
ENST00000582818 ENSP00000464252
ENST00000584888
ENST00000584450 ENSP00000463714
ENST00000582648 ENSP00000462024
ENST00000583391
ENST00000578373 ENSP00000463427
ENST00000583038
ENST00000584099 ENSP00000462270
ENST00000584601 ENSP00000462438
ENST00000582788
ENST00000584014
ENST00000584684
ENST00000578199 ENSP00000462808
ENST00000580074 ENSP00000463002
ENST00000578709 ENSP00000463719
ENST00000584908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 209 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 209 [view]
Protein-Protein 199 [view]
Protein-DNA 7 [view]
Protein-RNA 2 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001042 RNA polymerase I core binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007528 neuromuscular junction development
GO:0008045 motor neuron axon guidance
GO:0008283 cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030307 positive regulation of cell growth
GO:0030879 mammary gland development
GO:0032321 positive regulation of Rho GTPase activity
GO:0032886 regulation of microtubule-based process
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042552 myelination
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0045727 positive regulation of translation
GO:0045765 regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045943 positive regulation of transcription from RNA polymerase I promoter
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048709 oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0043235 receptor complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
TNFalpha pathway
IL6 pathway
Leptin pathway
Prolactin pathway
Oncostatin_M pathway
REACTOME
Signaling by FGFR in disease pathway
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
Semaphorin interactions pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
GRB2 events in ERBB2 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
SHC1 events in ERBB2 signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
PLCG1 events in ERBB2 signaling pathway
Sema4D induced cell migration and growth-cone collapse pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
GRB7 events in ERBB2 signaling pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
ErbB signaling pathway pathway
Calcium signaling pathway pathway
Focal adhesion pathway
Adherens junction pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Prostate cancer pathway
Bladder cancer pathway
Non-small cell lung cancer pathway
INOH
PID BIOCARTA
Role of erbb2 in signal transduction and oncology [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
PID NCI
ErbB4 signaling events
a6b1 and a6b4 Integrin signaling
Validated targets of C-MYC transcriptional repression
ErbB2/ErbB3 signaling events
ErbB receptor signaling network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446352
RefSeq NM_001005862 NM_001289936 NM_001289937 NM_001289938 NM_004448 XM_005257140 XM_006721766 XM_006721768
HUGO
OMIM
CCDS CCDS32642 CCDS45667 CCDS74052
HPRD 01281
IMGT
EMBL
GenPept
RNA Seq Atlas