InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZYX

Summary

InnateDB Gene

IDBG-46129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZYX

Gene Name

zyxin

Synonyms

ESP-2; HED-2

Species

Homo sapiens

Ensembl Gene

ENSG00000159840

Encoded Proteins

IDBP-46131

zyxin

IDBP-46133

zyxin

IDBP-244688

zyxin

IDBP-387079

zyxin

IDBP-387082

zyxin

IDBP-387084

zyxin

IDBP-387086

zyxin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:143381080-143391111

Strand

Forward strand

Band

q34

Transcripts

ENST00000322764	ENSP00000324422
ENST00000354434	ENSP00000346417
ENST00000392910	ENSP00000376642
ENST00000449630	ENSP00000413467
ENST00000457235	ENSP00000400537
ENST00000436448	ENSP00000411230
ENST00000446634	ENSP00000403714
ENST00000468083
ENST00000477373
ENST00000497119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0016032	viral process
GO:0050727	regulation of inflammatory response

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005913	cell-cell adherens junction
GO:0005925	focal adhesion

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029860

View Gene Order

ENSBTAG00000017970

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04510

Focal adhesion pathway

INOH

PID NCI

thrombin_par1_pathway

PAR1-mediated thrombin signaling events

ilk_pathway

Integrin-linked kinase signaling

ecadherin_stabilization_pathway

Stabilization and expansion of the E-cadherin adherens junction

ecadherin_keratinocyte_pathway

E-cadherin signaling in keratinocytes

Cross-References

SwissProt

TrEMBL

H7C3R3

UniProt Splice Variant

Entrez Gene

7791

UniGene

RefSeq

NM_001010972 NM_003461 XM_005250052 XM_005250053

HUGO

HGNC:13200

OMIM

602002

CCDS

CCDS5883

HPRD

03592

IMGT

EMBL

AC092214

GenPept

RNA Seq Atlas

7791