InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SSRP1

Summary

InnateDB Gene

IDBG-46402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSRP1

Gene Name

structure specific recognition protein 1

Synonyms

FACT; FACT80; T160

Species

Homo sapiens

Ensembl Gene

ENSG00000149136

Encoded Proteins

IDBP-46404

structure specific recognition protein 1

IDBP-592634

structure specific recognition protein 1

IDBP-599128

structure specific recognition protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:57325985-57335877

Strand

Reverse strand

Band

q12.1

Transcripts

ENST00000293880
ENST00000278412	ENSP00000278412
ENST00000526696	ENSP00000431154
ENST00000529002	ENSP00000434546

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	97 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription