InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SSRP1

Summary

InnateDB Protein

IDBP-46404.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSRP1

Protein Name

structure specific recognition protein 1

Synonyms

FACT; FACT80; T160;

Species

Homo sapiens

Ensembl Protein

ENSP00000278412

InnateDB Gene

IDBG-46402 (SSRP1)

Protein Structure

UniProt Annotation

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269PubMed:10912001, ECO:0000269PubMed:11239457, ECO:0000269PubMed:12374749, ECO:0000269PubMed:12934006, ECO:0000269PubMed:16713563, ECO:0000269PubMed:9489704, ECO:0000269PubMed:9566881, ECO:0000269PubMed:9836642}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	97 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000969 Structure-specific recognition protein
IPR009071 High mobility group box domain
IPR013719 Domain of unknown function DUF1747
IPR024954 SSRP1 domain

PFAM

PF00505
PF09011
PF08512
PF03531

PRINTS

PR00887

PIRSF

SMART

SM00398

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt