Homo sapiens Gene: HNRPLL
Summary
InnateDB Gene IDBG-46416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRPLL
Gene Name heterogeneous nuclear ribonucleoprotein L-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143889
Encoded Proteins
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
heterogeneous nuclear ribonucleoprotein L-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:38561978-38603586
Strand Reverse strand
Band p22.1
Transcripts
ENST00000378915 ENSP00000368195
ENST00000272249 ENSP00000272249
ENST00000358367 ENSP00000351136
ENST00000409636 ENSP00000387088
ENST00000409328 ENSP00000386575
ENST00000410076 ENSP00000386695
ENST00000449105 ENSP00000390625
ENST00000441689 ENSP00000415766
ENST00000425682 ENSP00000396669
ENST00000488099
ENST00000498516
ENST00000608859 ENSP00000476852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0033120 positive regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445497
RefSeq NM_001142650 NM_138394
HUGO
OMIM
CCDS CCDS1796 CCDS46261
HPRD 13667
IMGT
EMBL
GenPept
RNA Seq Atlas