Version 5.4
Homo sapiens Gene: HNRPLL
Summary
InnateDB Gene IDBG-46416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRPLL
Gene Name heterogeneous nuclear ribonucleoprotein L-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143889
Encoded Proteins
IDBP-46418
heterogeneous nuclear ribonucleoprotein L-like
IDBP-46422
heterogeneous nuclear ribonucleoprotein L-like
IDBP-46424
heterogeneous nuclear ribonucleoprotein L-like
IDBP-293988
heterogeneous nuclear ribonucleoprotein L-like
IDBP-293983
heterogeneous nuclear ribonucleoprotein L-like
IDBP-293977
heterogeneous nuclear ribonucleoprotein L-like
IDBP-372965
heterogeneous nuclear ribonucleoprotein L-like
IDBP-372980
heterogeneous nuclear ribonucleoprotein L-like
IDBP-372988
heterogeneous nuclear ribonucleoprotein L-like
IDBP-813155
heterogeneous nuclear ribonucleoprotein L-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:38561978-38603586
Strand Reverse strand
Band p22.1
Transcripts
ENST00000378915 ENSP00000368195
ENST00000272249 ENSP00000272249
ENST00000358367 ENSP00000351136
ENST00000409636 ENSP00000387088
ENST00000409328 ENSP00000386575
ENST00000410076 ENSP00000386695
ENST00000449105 ENSP00000390625
ENST00000441689 ENSP00000415766
ENST00000425682 ENSP00000396669
ENST00000488099
ENST00000498516
ENST00000608859 ENSP00000476852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0033120 positive regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024095
View Gene Order
ENSBTAG00000020567
Not yet available
Cross-References
SwissProt Q8WVV9
TrEMBL
UniProt Splice Variant
Entrez Gene 92906
UniGene Hs.445497
RefSeq NM_001142650 NM_138394
HUGO HGNC:25127
OMIM 611208
CCDS CCDS46261 CCDS1796
HPRD 13667
IMGT
EMBL AC011247 AF461712 AF461713 AF461714 AF461715 AF461716 AF461717 AF461718 AF461719 AF461720 AF461721 AF461722 AK291462 AL512692 AY236962 AY236963 BC008217 BC017480
GenPept AAH08217 AAH17480 AAN76189 AAN76190 AAQ20083 AAQ20084 AAY24302 BAF84151 CAH56358
RNA Seq Atlas 92906

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca