Version 5.4
Homo sapiens Gene: UFSP2
Summary
InnateDB Gene IDBG-46906.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UFSP2
Gene Name UFM1-specific peptidase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109775
Encoded Proteins
IDBP-46908
UFM1-specific peptidase 2
IDBP-477504
UFM1-specific peptidase 2
IDBP-479427
UFM1-specific peptidase 2
IDBP-476527
UFM1-specific peptidase 2
IDBP-478688
UFM1-specific peptidase 2
IDBP-476368
UFM1-specific peptidase 2
IDBP-478531
UFM1-specific peptidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Like ubiquitin (see MIM 191339), ubiquitin-fold modifier-1 (UFM1; MIM 610553) must be processed by a protease before it can conjugate with its target proteins. UFSP2 is a thiol protease that specifically processes the C terminus of UFM1 (Kang et al., 2007 [PubMed 17182609]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:185399540-185425985
Strand Reverse strand
Band q35.1
Transcripts
ENST00000264689 ENSP00000264689
ENST00000514247 ENSP00000423599
ENST00000510206
ENST00000510755 ENSP00000421133
ENST00000511485 ENSP00000425855
ENST00000509180 ENSP00000423657
ENST00000502428 ENSP00000424419
ENST00000502282
ENST00000505357 ENSP00000423108
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016790 thiolester hydrolase activity
GO:0019783 small conjugating protein-specific protease activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031634
View Gene Order
ENSBTAG00000018454
Not yet available
Cross-References
SwissProt
TrEMBL D6RA67 D6RGX2
UniProt Splice Variant
Entrez Gene 55325
UniGene
RefSeq NM_018359
HUGO HGNC:25640
OMIM 611482
CCDS CCDS3842
HPRD 07741
IMGT
EMBL AC106897
GenPept
RNA Seq Atlas 55325

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca