Version 5.4
Homo sapiens Protein: UFSP2
Summary
InnateDB Protein IDBP-46908.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UFSP2
Protein Name UFM1-specific peptidase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264689
InnateDB Gene IDBG-46906 (UFSP2)
Protein Structure
UniProt Annotation
Function Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016790 thiolester hydrolase activity
GO:0019783 small conjugating protein-specific protease activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR012462 Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2
PFAM PF07910
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NUQ7
PhosphoSite PhosphoSite-Q9NUQ7
TrEMBL D6RA67
UniProt Splice Variant
Entrez Gene 55325
UniGene
RefSeq NP_060829
HUGO HGNC:25640
OMIM 611482
CCDS CCDS3842
HPRD 07741
IMGT
EMBL AC106897 AK002062 BC010493 CR457278
GenPept AAH10493 BAA92064 CAG33559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca