Version 5.4
Homo sapiens Gene: MED24
Summary
InnateDB Gene IDBG-46943.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED24
Gene Name mediator complex subunit 24
Synonyms ARC100; CRSP100; CRSP4; DRIP100; THRAP4; TRAP100
Species Homo sapiens
Ensembl Gene ENSG00000008838
Encoded Proteins
IDBP-46945
mediator complex subunit 24
IDBP-242208
mediator complex subunit 24
IDBP-242210
mediator complex subunit 24
IDBP-242212
mediator complex subunit 24
IDBP-377581
mediator complex subunit 24
IDBP-377583
mediator complex subunit 24
IDBP-601872
mediator complex subunit 24
IDBP-585643
mediator complex subunit 24
IDBP-600266
mediator complex subunit 24
IDBP-600499
mediator complex subunit 24
IDBP-587057
mediator complex subunit 24
IDBP-587971
mediator complex subunit 24
IDBP-763219
IDBP-761648
IDBP-760189
IDBP-758798
IDBP-759274
IDBP-759021
IDBP-760633
IDBP-757872
IDBP-763871
IDBP-810069
mediator complex subunit 24
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40019097-40061215
Strand Reverse strand
Band q21.1
Transcripts
ENST00000356271 ENSP00000348610
ENST00000394128 ENSP00000377686
ENST00000394127 ENSP00000377685
ENST00000394126 ENSP00000377684
ENST00000422942 ENSP00000393464
ENST00000428757 ENSP00000392276
ENST00000501516 ENSP00000440100
ENST00000491466 ENSP00000435760
ENST00000470126
ENST00000492176
ENST00000495586
ENST00000479829
ENST00000543759 ENSP00000438630
ENST00000537674 ENSP00000438767
ENST00000535071 ENSP00000443344
ENST00000535508 ENSP00000439148
ENST00000579364
ENST00000578901 ENSP00000463484
ENST00000580008 ENSP00000463043
ENST00000580885 ENSP00000463751
ENST00000581058 ENSP00000463724
ENST00000577488
ENST00000578161 ENSP00000463480
ENST00000580720
ENST00000585306 ENSP00000462646
ENST00000582023 ENSP00000462539
ENST00000580921
ENST00000580517 ENSP00000463528
ENST00000580302 ENSP00000464225
ENST00000584077
ENST00000581054
ENST00000585249
ENST00000584782
ENST00000614384 ENSP00000482676
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 82 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0004872 receptor activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042809 vitamin D receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0016573 histone acetylation
GO:0019827 stem cell maintenance
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051291 protein heterooligomerization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017210
View Gene Order
ENSBTAG00000021468
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9862
UniGene Hs.462983
RefSeq NM_001079518 NM_001267797 NM_014815 XM_005257872 XM_005257873 XM_005257874 XM_006722204 XM_006722206 XM_006722207
HUGO HGNC:22963
OMIM 607000
CCDS CCDS11359 CCDS42315
HPRD 06107
IMGT
EMBL
GenPept
RNA Seq Atlas 102466757 9862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca