InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: YEATS4

Summary

InnateDB Gene

IDBG-47114.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YEATS4

Gene Name

YEATS domain containing 4

Synonyms

4930573H17Rik; B230215M10Rik; GAS41; NUBI-1; YAF9

Species

Homo sapiens

Ensembl Gene

ENSG00000127337

Encoded Proteins

IDBP-47116

YEATS domain containing 4

IDBP-599678

YEATS domain containing 4

IDBP-593719

YEATS domain containing 4

IDBP-589356

YEATS domain containing 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:69359703-69390796

Strand

Forward strand

Band

q15

Transcripts

ENST00000247843	ENSP00000247843
ENST00000548020	ENSP00000447199
ENST00000549685	ENSP00000448106
ENST00000552949
ENST00000552955	ENSP00000446985

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0040008	regulation of growth
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016363	nuclear matrix
GO:0035267	NuA4 histone acetyltransferase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020171

View Gene Order

ENSBTAG00000002256

Not yet available

Pathways

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001300950 NM_006530 XM_005269163

HUGO

OMIM

CCDS

CCDS73495 CCDS8990

HPRD

03666

IMGT

EMBL

GenPept

RNA Seq Atlas