InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YEATS4

Summary

InnateDB Protein

IDBP-47116.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YEATS4

Protein Name

YEATS domain containing 4

Synonyms

4930573H17Rik; B230215M10Rik; GAS41; NUBI-1; YAF9;

Species

Homo sapiens

Ensembl Protein

ENSP00000247843

InnateDB Gene

IDBG-47114 (YEATS4)

Protein Structure

UniProt Annotation

Function

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. {ECO:0000269PubMed:14966270}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00376, ECO:0000269PubMed:10913114}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269PubMed:10913114}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0040008	regulation of growth
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation
GO:0045893	positive regulation of transcription, DNA-templated