InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTPS2

Summary

InnateDB Gene

IDBG-47158.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTPS2

Gene Name

CTP synthase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000047230

Encoded Proteins

IDBP-47160

CTP synthase II

IDBP-47162

CTP synthase II

IDBP-362960

CTP synthase II

IDBP-362962

CTP synthase II

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:16588003-16712936

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000380241	ENSP00000369590
ENST00000359276	ENSP00000352222
ENST00000443824	ENSP00000401264
ENST00000455276	ENSP00000400431
ENST00000483053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0006220	pyrimidine nucleotide metabolic process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006541	glutamine metabolic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0044210	'de novo' CTP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000031360

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000017017

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID BIOCARTA

PID NCI

Cross-References

SwissProt

Q9NRF8

TrEMBL

A0A024RC00

UniProt Splice Variant

Entrez Gene

56474

UniGene

Hs.227049

RefSeq

NM_019857 NM_175859 NM_001144002 XM_006724503 XM_005274562

HUGO

HGNC:2520

OMIM

300380

CCDS

CCDS14175

HPRD

02305

IMGT

EMBL

AC073909 AF226667 AK023549 AK024070 AK125332 AK125348 AL445467 BC006256 BC034986 CH471074

GenPept

AAF91241 AAH06256 AAH34986 BAB14607 BAB14814 BAG54184 BAG54188 CAI40086 EAW98912 EAW98914 EAW98915

RNA Seq Atlas

56474