Homo sapiens Gene: CTPS2
Summary
InnateDB Gene IDBG-47158.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTPS2
Gene Name CTP synthase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000047230
Encoded Proteins
CTP synthase II
CTP synthase II
CTP synthase II
CTP synthase II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:16588003-16712936
Strand Reverse strand
Band p22.2
Transcripts
ENST00000380241 ENSP00000369590
ENST00000359276 ENSP00000352222
ENST00000443824 ENSP00000401264
ENST00000455276 ENSP00000400431
ENST00000483053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003883 CTP synthase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006541 glutamine metabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0044210 'de novo' CTP biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis and interconversion of nucleotide di- and triphosphates pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Pyrimidine metabolism pathway
INOH
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NRF8
TrEMBL A0A024RC00
UniProt Splice Variant
Entrez Gene 56474
UniGene Hs.227049
RefSeq NM_019857 NM_175859 NM_001144002 XM_006724503 XM_005274562
HUGO HGNC:2520
OMIM 300380
CCDS CCDS14175
HPRD 02305
IMGT
EMBL AC073909 AF226667 AK023549 AK024070 AK125332 AK125348 AL445467 BC006256 BC034986 CH471074
GenPept AAF91241 AAH06256 AAH34986 BAB14607 BAB14814 BAG54184 BAG54188 CAI40086 EAW98912 EAW98914 EAW98915
RNA Seq Atlas 56474