Version 5.4
Homo sapiens Protein: CTPS2
Summary
InnateDB Protein IDBP-47160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTPS2
Protein Name CTP synthase II
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369590
InnateDB Gene IDBG-47158 (CTPS2)
Protein Structure
UniProt Annotation
Function Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269PubMed:10899599, ECO:0000269PubMed:16179339}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003883 CTP synthase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006541 glutamine metabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0044210 'de novo' CTP biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR004468 CTP synthase
IPR011697 Peptidase C26
IPR017456 CTP synthase, N-terminal
IPR017926 Glutamine amidotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029062 Class I glutamine amidotransferase-like
PFAM PF07722
PF06418
PF00117
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRF8
PhosphoSite PhosphoSite-Q9NRF8
TrEMBL A0A024RC00
UniProt Splice Variant
Entrez Gene 56474
UniGene Hs.227049
RefSeq NP_062831
HUGO HGNC:2520
OMIM 300380
CCDS CCDS14175
HPRD 02305
IMGT
EMBL AC073909 AF226667 AK023549 AK024070 AK125332 AK125348 AL445467 BC006256 BC034986 CH471074
GenPept AAF91241 AAH06256 AAH34986 BAB14607 BAB14814 BAG54184 BAG54188 CAI40086 EAW98912 EAW98914 EAW98915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca