Homo sapiens Gene: CASC3
Summary
InnateDB Gene IDBG-47220.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASC3
Gene Name cancer susceptibility candidate 3
Synonyms BTZ; MLN51;
Species Homo sapiens
Ensembl Gene ENSG00000108349
Encoded Proteins
cancer susceptibility candidate 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40140318-40172183
Strand Forward strand
Band q21.1
Transcripts
ENST00000264645 ENSP00000264645
ENST00000394114
ENST00000418132
ENST00000474190 ENSP00000462713
ENST00000577605 ENSP00000464626
ENST00000583902
ENST00000583649
ENST00000579238
ENST00000581849
ENST00000584997 ENSP00000467654
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006397 mRNA processing
GO:0006417 regulation of translation
GO:0006950 response to stress
GO:0008150 biological_process
GO:0008298 intracellular mRNA localization
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0030529 ribonucleoprotein complex
GO:0035145 exon-exon junction complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Gene Expression pathway
KEGG
RNA transport pathway
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL K7EQ38
UniProt Splice Variant
Entrez Gene 22794
UniGene Hs.743287
RefSeq NM_007359 XM_005257163
HUGO HGNC:17040
OMIM 606504
CCDS CCDS11362
HPRD 16225
IMGT
EMBL AC068669
GenPept
RNA Seq Atlas 102466986 22794