InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HSPA9

Summary

InnateDB Gene

IDBG-47262.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA9

Gene Name

heat shock 70kDa protein 9 (mortalin)

Synonyms

CRP40; CSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74

Species

Homo sapiens

Ensembl Gene

ENSG00000113013

Encoded Proteins

IDBP-47264

heat shock 70kDa protein 9 (mortalin)

IDBP-477084

heat shock 70kDa protein 9 (mortalin)

IDBP-485484

heat shock 70kDa protein 9 (mortalin)

IDBP-477668

heat shock 70kDa protein 9 (mortalin)

IDBP-479266

heat shock 70kDa protein 9 (mortalin)

IDBP-476069

heat shock 70kDa protein 9 (mortalin)

IDBP-482351

heat shock 70kDa protein 9 (mortalin)

IDBP-477613

heat shock 70kDa protein 9 (mortalin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:138554882-138575444

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000297185	ENSP00000297185
ENST00000501917
ENST00000524109
ENST00000512328	ENSP00000421892
ENST00000507097
ENST00000523929	ENSP00000429475
ENST00000508003
ENST00000504902	ENSP00000421311
ENST00000507115	ENSP00000423759
ENST00000505110	ENSP00000420944
ENST00000504810	ENSP00000425598
ENST00000506477
ENST00000507886	ENSP00000423098

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 155 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	155 [view]
Protein-Protein	153 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0005975	carbohydrate metabolic process
GO:0006457	protein folding
GO:0006611	protein export from nucleus
GO:0006626	protein targeting to mitochondrion
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024359

View Gene Order

ENSBTAG00000011419

Not yet available

Pathways

NETPATH

REACTOME

REACT_118595

Mitochondrial protein import pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

P38646

TrEMBL

D6RA73 D6RJI2

UniProt Splice Variant

Entrez Gene

3313

UniGene

Hs.184233 Hs.615161

RefSeq

NM_004134

HUGO

HGNC:5244

OMIM

600548

CCDS

CCDS4208

HPRD

02770

IMGT

EMBL

AC011385 AC113340 AK222758 AK315177 BC000478 BC024034 CH471062 DQ531046 L11066 L15189

GenPept

AAA67526 AAH00478 AAH24034 ABF50973 BAD96478 BAG37618 EAW62129

RNA Seq Atlas

3313