InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPA9

Summary

InnateDB Protein

IDBP-47264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA9

Protein Name

heat shock 70kDa protein 9 (mortalin)

Synonyms

CRP40; CSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74;

Species

Homo sapiens

Ensembl Protein

ENSP00000297185

InnateDB Gene

IDBG-47262 (HSPA9)

Protein Structure

UniProt Annotation

Function

Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. {ECO:0000269PubMed:23501103}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:22002106}. Nucleus, nucleolus {ECO:0000269PubMed:22002106}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 155 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	155 [view]
Protein-Protein	153 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0005975	carbohydrate metabolic process
GO:0006457	protein folding
GO:0006611	protein export from nucleus
GO:0006626	protein targeting to mitochondrion
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR012725 Chaperone DnaK
IPR013126 Heat shock protein 70 family
IPR018485 Carbohydrate kinase, FGGY, C-terminal
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012
PF02782

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P38646