Homo sapiens Gene: SOS1
InnateDB Gene IDBG-47279.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOS1
Gene Name son of sevenless homolog 1 (Drosophila)
Synonyms GF1; GGF1; GINGF; HGF; NS4;
Species Homo sapiens
Ensembl Gene ENSG00000115904
Encoded Proteins
son of sevenless homolog 1 (Drosophila)
son of sevenless homolog 1 (Drosophila)
son of sevenless homolog 1 (Drosophila)
son of sevenless homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:38981396-39124345
Strand Reverse strand
Band p22.1
ENST00000395038 ENSP00000378479
ENST00000402219 ENSP00000384675
ENST00000426016 ENSP00000387784
ENST00000451331 ENSP00000393899
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 71 [view]
Protein-Protein 71 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030168 platelet activation
GO:0032318 regulation of Ras GTPase activity
GO:0032320 positive regulation of Ras GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0043025 neuronal cell body
Mus musculus
Bos taurus
Gene ID
Gene Order
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
Prolactin pathway
Oncostatin_M pathway
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
SHC-related events pathway
G alpha (12/13) signalling events pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
FRS2-mediated cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Rho GTPases pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
Signaling by constitutively active EGFR pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
SHC-related events triggered by IGF1R pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
Activation of Rac pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Tie2 Signaling pathway
IRS-mediated signalling pathway
Integrin alphaIIb beta3 signaling pathway
NRAGE signals death through JNK pathway
SHC1 events in EGFR signaling pathway
Adaptive Immune System pathway
SHC-mediated signalling pathway
Immune System pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
Insulin receptor signalling cascade pathway
Rho GTPase cycle pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Signaling by Interleukins pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
Platelet Aggregation (Plug Formation) pathway
IRS-related events pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
SHC1 events in ERBB2 signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
IGF1R signaling cascade pathway
Signal attenuation pathway
EGFR Transactivation by Gastrin pathway
Signaling by FGFR pathway
Signaling by Robo receptor pathway
Signalling to RAS pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Regulation of KIT signaling pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
Cell surface interactions at the vascular wall pathway
Disease pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Dorso-ventral axis formation pathway
Focal adhesion pathway
Gap junction pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Hepatitis C pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
Inhibition of cellular proliferation by gleevec [Biocarta view]
Il 2 signaling pathway [Biocarta view]
Il 3 signaling pathway [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Il 6 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Epo signaling pathway [Biocarta view]
Bcr signaling pathway [Biocarta view]
Integrin signaling pathway [Biocarta view]
Map kinase inactivation of smrt corepressor [Biocarta view]
Trka receptor signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
Insulin signaling pathway [Biocarta view]
Ras signaling pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Pten dependent cell cycle arrest and apoptosis [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
Trk receptor signaling mediated by PI3K and PLC-gamma
TCR signaling in na´ve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Regulation of RAC1 activity
IL2-mediated signaling events
TCR signaling in na´ve CD4+ T cells
Internalization of ErbB1
VEGFR3 signaling in lymphatic endothelium
ErbB1 downstream signaling
Signaling events mediated by focal adhesion kinase
IGF1 pathway
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
FGF signaling pathway
BCR signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
EGFR-dependent Endothelin signaling events
Signaling events mediated by TCPTP
Regulation of Ras family activation
ErbB2/ErbB3 signaling events
Plasma membrane estrogen receptor signaling
Signaling events regulated by Ret tyrosine kinase
TGF-beta receptor signaling
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
PDGFR-alpha signaling pathway
IL2 signaling events mediated by PI3K
PDGFR-beta signaling pathway
IL6-mediated signaling events
Insulin Pathway
UniProt Splice Variant
Entrez Gene
UniGene Hs.604256 Hs.709893
RefSeq NM_005633
HPRD 01681
RNA Seq Atlas