Homo sapiens Gene: AKR1C2
Summary
InnateDB Gene IDBG-47297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKR1C2
Gene Name aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
Synonyms AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD;
Species Homo sapiens
Ensembl Gene ENSG00000151632
Encoded Proteins
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
aldo-keto reductase family 1, member C2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:4922564-5135226
Strand Reverse strand
Band p15.1
Transcripts
ENST00000380753 ENSP00000370129
ENST00000407674 ENSP00000385221
ENST00000421196 ENSP00000392694
ENST00000455190 ENSP00000408440
ENST00000460124
ENST00000604507 ENSP00000474566
ENST00000604184
ENST00000604428
ENST00000604711
ENST00000603073
ENST00000604439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0004958 prostaglandin F receptor activity
GO:0016491 oxidoreductase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 phenanthrene 9,10-monooxygenase activity
GO:0031406 carboxylic acid binding
GO:0032052 bile acid binding
GO:0047086 ketosteroid monooxygenase activity
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007586 digestion
GO:0008202 steroid metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0030855 epithelial cell differentiation
GO:0034694 response to prostaglandin stimulus
GO:0042448 progesterone metabolic process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0051897 positive regulation of protein kinase B signaling
GO:0055114 oxidation-reduction process
GO:0071395 cellular response to jasmonic acid stimulus
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Bile acid and bile salt metabolism pathway
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
Synthesis of bile acids and bile salts pathway
Metabolism pathway
KEGG
Steroid hormone biosynthesis pathway
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001135241 NM_001354 NM_205845
HUGO
OMIM
CCDS CCDS44350 CCDS7062
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas