Version 5.4
Homo sapiens Gene: ADAM33
Summary
InnateDB Gene IDBG-47331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM33
Gene Name ADAM metallopeptidase domain 33
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149451
Encoded Proteins
IDBP-47333
ADAM metallopeptidase domain 33
IDBP-47337
ADAM metallopeptidase domain 33
IDBP-47339
ADAM metallopeptidase domain 33
IDBP-808855
ADAM metallopeptidase domain 33
IDBP-808860
ADAM metallopeptidase domain 33
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3667965-3682246
Strand Reverse strand
Band p13
Transcripts
ENST00000379861 ENSP00000369190
ENST00000356518 ENSP00000348912
ENST00000350009 ENSP00000322550
ENST00000466620
ENST00000483362
ENST00000617732 ENSP00000483343
ENST00000619289 ENSP00000484600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0045087 innate immune response
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027318
View Gene Order
ENSBTAG00000013163
Not yet available
Cross-References
SwissProt Q9BZ11
TrEMBL A2A2L3 Q08AM2 Q08AM3 Q8N6B9
UniProt Splice Variant
Entrez Gene 80332
UniGene
RefSeq NM_001282447 NM_025220 NM_153202
HUGO HGNC:15478
OMIM 607114
CCDS CCDS13058 CCDS63219
HPRD
IMGT
EMBL AB055891 AF466287 AF466288 AF466289 AL109804 AL356755 AY358314 BC125112 BC125113 CH471133 DQ995342
GenPept AAI25113 AAI25114 AAM80482 AAM80483 AAM80484 AAQ88680 ABI97387 BAB83092 CAI18840 EAX10525
RNA Seq Atlas 80332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca