Homo sapiens Gene: ADAM33
Summary
InnateDB Gene IDBG-47331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM33
Gene Name ADAM metallopeptidase domain 33
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149451
Encoded Proteins
ADAM metallopeptidase domain 33
ADAM metallopeptidase domain 33
ADAM metallopeptidase domain 33
ADAM metallopeptidase domain 33
ADAM metallopeptidase domain 33
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3667965-3682246
Strand Reverse strand
Band p13
Transcripts
ENST00000379861 ENSP00000369190
ENST00000356518 ENSP00000348912
ENST00000350009 ENSP00000322550
ENST00000466620
ENST00000483362
ENST00000617732 ENSP00000483343
ENST00000619289 ENSP00000484600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0045087 innate immune response
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001282447 NM_025220 NM_153202
HUGO
OMIM
CCDS CCDS13058 CCDS63219
HPRD 06173
IMGT
EMBL
GenPept
RNA Seq Atlas