Homo sapiens Gene: CDC6
Summary
InnateDB Gene IDBG-47359.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC6
Gene Name cell division cycle 6 homolog (S. cerevisiae)
Synonyms CDC18L; HsCDC18; HsCDC6;
Species Homo sapiens
Ensembl Gene ENSG00000094804
Encoded Proteins
cell division cycle 6 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40287633-40304657
Strand Forward strand
Band q21.2
Transcripts
ENST00000209728 ENSP00000209728
ENST00000473555 ENSP00000464047
ENST00000577249 ENSP00000463004
ENST00000582402
ENST00000580824 ENSP00000463635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 63 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
GO:0019900 kinase binding
Biological Process
GO:0000076 DNA replication checkpoint
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0007067 mitotic nuclear division
GO:0007089 traversing start control point of mitotic cell cycle
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell proliferation
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0032467 positive regulation of cytokinesis
GO:0051984 positive regulation of chromosome segregation
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005819 spindle
GO:0005829 cytosol
GO:0051233 spindle midzone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
G1/S-Specific Transcription pathway
Cell Cycle pathway
Association of licensing factors with the pre-replicative complex pathway
Removal of licensing factors from origins pathway
G0 and Early G1 pathway
E2F mediated regulation of DNA replication pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
CDT1 association with the CDC6:ORC:origin complex pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
PID NCI
E2F transcription factor network
ATR signaling pathway
Cross-References
SwissProt
TrEMBL J3KTI7 J3QLN7 J3QR52
UniProt Splice Variant
Entrez Gene 990
UniGene Hs.405958
RefSeq NM_001254
HUGO HGNC:1744
OMIM 602627
CCDS CCDS11365
HPRD 04022
IMGT
EMBL AC080112
GenPept
RNA Seq Atlas 990