InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC6

Summary

InnateDB Gene

IDBG-47359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC6

Gene Name

cell division cycle 6 homolog (S. cerevisiae)

Synonyms

CDC18L; HsCDC18; HsCDC6

Species

Homo sapiens

Ensembl Gene

ENSG00000094804

Encoded Proteins

IDBP-47361

cell division cycle 6 homolog (S. cerevisiae)

IDBP-764488

IDBP-758150

IDBP-763230

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:40287633-40304657

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000209728	ENSP00000209728
ENST00000473555	ENSP00000464047
ENST00000577249	ENSP00000463004
ENST00000582402
ENST00000580824	ENSP00000463635

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	63 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0019900	kinase binding

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0007067	mitotic nuclear division
GO:0007089	traversing start control point of mitotic cell cycle
GO:0008156	negative regulation of DNA replication
GO:0008285	negative regulation of cell proliferation
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0032467	positive regulation of cytokinesis
GO:0051984	positive regulation of chromosome segregation

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005819	spindle
GO:0005829	cytosol
GO:0051233	spindle midzone