Version 5.4
Homo sapiens Gene: CTNNA1
Summary
InnateDB Gene IDBG-47369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNNA1
Gene Name catenin (cadherin-associated protein), alpha 1, 102kDa
Synonyms CAP102
Species Homo sapiens
Ensembl Gene ENSG00000044115
Encoded Proteins
IDBP-47371
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-476979
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-483846
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-485480
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-483852
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-480394
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-477913
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-484196
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-480105
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-485477
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-478845
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-477657
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-477719
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-482448
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-483379
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-482090
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-478997
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-475318
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-475547
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-477944
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-473990
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-479398
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-477553
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-484728
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-479021
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-475546
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-813147
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-480452
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-475954
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-481425
catenin (cadherin-associated protein), alpha 1, 102kDa
IDBP-598991
catenin (cadherin-associated protein), alpha 1, 102kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:138610967-138935034
Strand Forward strand
Band q31.2
Transcripts
ENST00000302763 ENSP00000304669
ENST00000517980 ENSP00000428439
ENST00000522227 ENSP00000429636
ENST00000524127 ENSP00000428049
ENST00000523912 ENSP00000430304
ENST00000520339 ENSP00000428202
ENST00000521724 ENSP00000431033
ENST00000518910 ENSP00000430626
ENST00000521941
ENST00000519309 ENSP00000430671
ENST00000519113 ENSP00000430078
ENST00000520158 ENSP00000429457
ENST00000518825 ENSP00000427821
ENST00000518585
ENST00000518919
ENST00000523275 ENSP00000429142
ENST00000522730
ENST00000517534
ENST00000520400
ENST00000518381 ENSP00000429738
ENST00000522013 ENSP00000430379
ENST00000520260 ENSP00000429569
ENST00000524292
ENST00000523298 ENSP00000428044
ENST00000520865 ENSP00000430841
ENST00000519634 ENSP00000428088
ENST00000517533 ENSP00000431118
ENST00000523685 ENSP00000430240
ENST00000518263
ENST00000519768 ENSP00000429103
ENST00000517656 ENSP00000430177
ENST00000521683 ENSP00000430981
ENST00000521640 ENSP00000430623
ENST00000519116 ENSP00000428894
ENST00000522052 ENSP00000482738
ENST00000520522 ENSP00000428710
ENST00000517904
ENST00000521368 ENSP00000428686
ENST00000521387
ENST00000519489
ENST00000520520 ENSP00000430076
ENST00000522792
ENST00000540387 ENSP00000438476
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 81 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0017166 vinculin binding
GO:0044822 poly(A) RNA binding
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0001541 ovarian follicle development
GO:0007155 cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007406 negative regulation of neuroblast proliferation
GO:0007568 aging
GO:0008584 male gonad development
GO:0014070 response to organic cyclic compound
GO:0016264 gap junction assembly
GO:0031103 axon regeneration
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0034613 cellular protein localization
GO:0042127 regulation of cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042692 muscle cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0043297 apical junction assembly
GO:0043627 response to estrogen
GO:0045216 cell-cell junction organization
GO:0045880 positive regulation of smoothened signaling pathway
GO:0051149 positive regulation of muscle cell differentiation
GO:0051291 protein heterooligomerization
GO:0071681 cellular response to indole-3-methanol
GO:0090136 epithelial cell-cell adhesion
GO:2000146 negative regulation of cell motility
GO:2001045 negative regulation of integrin-mediated signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0014704 intercalated disc
GO:0015629 actin cytoskeleton
GO:0016342 catenin complex
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037815
View Gene Order
ENSBTAG00000014182
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_111102
Signal Transduction pathway
REACT_21303
Myogenesis pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
nectin_pathway
Nectin adhesion pathway
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
arf6_traffickingpathway
Arf6 trafficking events
ncadherinpathway
N-cadherin signaling events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL E5RFM3 E5RHV7 E5RIE0 E5RJL0
UniProt Splice Variant
Entrez Gene 1495
UniGene Hs.445981 Hs.740112
RefSeq NM_001290307 NM_001290309 NM_001290310 NM_001290312 NM_001903 XM_005271898 XM_005271899 XM_006714536
HUGO HGNC:2509
OMIM 116805
CCDS CCDS34243 CCDS75315
HPRD 00285
IMGT
EMBL AC010453 AC011405 AC034243 AC113340
GenPept
RNA Seq Atlas 1495

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca