InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTNNA1

Summary

InnateDB Protein

IDBP-47371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTNNA1

Protein Name

catenin (cadherin-associated protein), alpha 1, 102kDa

Synonyms

CAP102;

Species

Homo sapiens

Ensembl Protein

ENSP00000304669

InnateDB Gene

IDBG-47369 (CTNNA1)

Protein Structure

UniProt Annotation

Function

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Subcellular Localization

Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.Isoform 3: Cell membrane {ECO:0000269PubMed:21708131}; Peripheral membrane protein {ECO:0000269PubMed:21708131}; Cytoplasmic side {ECO:0000269PubMed:21708131}.

Disease Associations

Tissue Specificity

Expressed ubiquitously in normal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	81 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0017166	vinculin binding
GO:0044822	poly(A) RNA binding
GO:0045295	gamma-catenin binding
GO:0045296	cadherin binding
GO:0051015	actin filament binding

Biological Process

GO:0001541	ovarian follicle development
GO:0007155	cell adhesion
GO:0007163	establishment or maintenance of cell polarity
GO:0007406	negative regulation of neuroblast proliferation
GO:0007568	aging
GO:0008584	male gonad development
GO:0014070	response to organic cyclic compound
GO:0016264	gap junction assembly
GO:0031103	axon regeneration
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0034613	cellular protein localization
GO:0042127	regulation of cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042692	muscle cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0043297	apical junction assembly
GO:0043627	response to estrogen
GO:0045216	cell-cell junction organization
GO:0045880	positive regulation of smoothened signaling pathway
GO:0051149	positive regulation of muscle cell differentiation
GO:0051291	protein heterooligomerization
GO:0071681	cellular response to indole-3-methanol
GO:0090136	epithelial cell-cell adhesion
GO:2000146	negative regulation of cell motility
GO:2001045	negative regulation of integrin-mediated signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005915	zonula adherens
GO:0014704	intercalated disc
GO:0015629	actin cytoskeleton
GO:0016342	catenin complex
GO:0030027	lamellipodium