Version 5.4
Homo sapiens Gene: CNOT2
Summary
InnateDB Gene IDBG-47581.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT2
Gene Name CCR4-NOT transcription complex, subunit 2
Synonyms CDC36; NOT2; NOT2H
Species Homo sapiens
Ensembl Gene ENSG00000111596
Encoded Proteins
IDBP-47583
CCR4-NOT transcription complex, subunit 2
IDBP-379985
CCR4-NOT transcription complex, subunit 2
IDBP-593762
CCR4-NOT transcription complex, subunit 2
IDBP-592114
CCR4-NOT transcription complex, subunit 2
IDBP-583913
CCR4-NOT transcription complex, subunit 2
IDBP-585965
CCR4-NOT transcription complex, subunit 2
IDBP-602728
CCR4-NOT transcription complex, subunit 2
IDBP-592875
CCR4-NOT transcription complex, subunit 2
IDBP-593225
CCR4-NOT transcription complex, subunit 2
IDBP-589425
CCR4-NOT transcription complex, subunit 2
IDBP-589605
CCR4-NOT transcription complex, subunit 2
IDBP-601544
CCR4-NOT transcription complex, subunit 2
IDBP-593054
CCR4-NOT transcription complex, subunit 2
IDBP-592395
CCR4-NOT transcription complex, subunit 2
IDBP-603415
CCR4-NOT transcription complex, subunit 2
IDBP-601545
CCR4-NOT transcription complex, subunit 2
IDBP-586145
CCR4-NOT transcription complex, subunit 2
IDBP-599461
CCR4-NOT transcription complex, subunit 2
IDBP-591614
CCR4-NOT transcription complex, subunit 2
IDBP-591430
CCR4-NOT transcription complex, subunit 2
IDBP-808060
CCR4-NOT transcription complex, subunit 2
IDBP-584091
CCR4-NOT transcription complex, subunit 2
IDBP-587163
CCR4-NOT transcription complex, subunit 2
IDBP-587670
CCR4-NOT transcription complex, subunit 2
IDBP-603411
CCR4-NOT transcription complex, subunit 2
IDBP-589208
CCR4-NOT transcription complex, subunit 2
IDBP-603409
CCR4-NOT transcription complex, subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:70242994-70354993
Strand Forward strand
Band q15
Transcripts
ENST00000229195 ENSP00000229195
ENST00000418359 ENSP00000412091
ENST00000552231 ENSP00000450318
ENST00000547780 ENSP00000450283
ENST00000552319 ENSP00000448453
ENST00000550160 ENSP00000448490
ENST00000551661 ENSP00000449385
ENST00000553078
ENST00000551132 ENSP00000449801
ENST00000548021
ENST00000552915 ENSP00000447497
ENST00000549443
ENST00000548741 ENSP00000448255
ENST00000552483 ENSP00000450077
ENST00000552422
ENST00000551179
ENST00000547321
ENST00000550641 ENSP00000448024
ENST00000553020 ENSP00000449084
ENST00000548159 ENSP00000449659
ENST00000549750 ENSP00000449577
ENST00000551043 ENSP00000449260
ENST00000547867 ENSP00000448660
ENST00000551873 ENSP00000450090
ENST00000550194 ENSP00000449446
ENST00000548599 ENSP00000449917
ENST00000552151 ENSP00000483096
ENST00000548863
ENST00000547149
ENST00000548230
ENST00000550155
ENST00000551483 ENSP00000448883
ENST00000549947
ENST00000552599 ENSP00000446507
ENST00000548939
ENST00000546673 ENSP00000448298
ENST00000548338 ENSP00000448808
ENST00000551434
ENST00000548686
ENST00000549709 ENSP00000447813
ENST00000551710 ENSP00000447808
ENST00000550705
ENST00000549705
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 30 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001226 RNA polymerase II transcription corepressor binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0001829 trophectodermal cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006417 regulation of translation
GO:0010467 gene expression
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031047 gene silencing by RNA
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020166
View Gene Order
ENSBTAG00000003748
Not yet available
Pathways
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001199302 NM_001199303 NM_014515
HUGO
OMIM
CCDS CCDS31857
HPRD 05367
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca