Version 5.4
Bos taurus Gene: BT.30639
Summary
InnateDB Gene IDBG-633809.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.30639
Gene Name CCR4-NOT transcription complex subunit 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003748
Encoded Proteins
IDBP-685595
CCR4-NOT transcription complex, subunit 2
IDBP-685600
CCR4-NOT transcription complex, subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111596:
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:43361161-43494162
Strand Reverse strand
Band
Transcripts
ENSBTAT00000057053 ENSBTAP00000049597
ENSBTAT00000004880 ENSBTAP00000004880
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001226 RNA polymerase II transcription corepressor binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001829 trophectodermal cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111596
View Gene Order
ENSMUSG00000020166
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
REACT_244119
Deadenylation of mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MID5
UniProt Splice Variant
Entrez Gene 533945
UniGene Bt.30639
RefSeq NM_001103277
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013212 DAAA02013213 DAAA02013214 DAAA02013215
GenPept
RNA Seq Atlas 533945

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca