Version 5.4
Homo sapiens Gene: PDCD1LG2
Summary
InnateDB Gene IDBG-47595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDCD1LG2
Gene Name programmed cell death 1 ligand 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197646
Encoded Proteins
IDBP-234678
programmed cell death 1 ligand 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21097698
PDCD1LG2 expression in macrophages is induced upon exposure to HIV virions, and is transcriptionally down-regulated by IL10.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:5510570-5571254
Strand Forward strand
Band p24.1
Transcripts
ENST00000397747 ENSP00000380855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0031295 T cell costimulation
GO:0042102 positive regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016498
View Gene Order
ENSBTAG00000033316
Not yet available
Pathways
NETPATH
REACTOME
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q9BQ51
TrEMBL
UniProt Splice Variant
Entrez Gene 80380
UniGene Hs.532279
RefSeq NM_025239 XM_005251600 XM_005251601 XM_005251602
HUGO HGNC:18731
OMIM 605723
CCDS CCDS6465
HPRD 16147
IMGT
EMBL AF329193 AF344424 AL162253 AY254343 AY271901 AY271902 BC074766 BC113678 BC113680
GenPept AAH74766 AAI13679 AAI13681 AAK15370 AAK31105 AAP13471 AAP49000 AAP49001 CAI15984
RNA Seq Atlas 80380

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca