InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDCD1LG2

Summary

InnateDB Protein

IDBP-234678.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD1LG2

Protein Name

programmed cell death 1 ligand 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380855

InnateDB Gene

IDBG-47595 (PDCD1LG2)

Protein Structure

UniProt Annotation

Function

Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 3: Secreted {ECO:0000305}.Isoform 2: Endomembrane system; Single-pass type I membrane protein.Isoform 1: Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. {ECO:0000269PubMed:11224527}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0045087	innate immune response (InnateDB)