Homo sapiens Gene: KCNMB4
Summary
InnateDB Gene IDBG-47624.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNMB4
Gene Name potassium large conductance calcium-activated channel, subfamily M, beta member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135643
Encoded Proteins
potassium large conductance calcium-activated channel, subfamily M, beta member 4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:70366276-70434292
Strand Forward strand
Band q15
Transcripts
ENST00000258111 ENSP00000258111
ENST00000531884 ENSP00000431137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
Biological Process
GO:0001508 action potential
GO:0005513 detection of calcium ion
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0019228 neuronal action potential
GO:0019229 regulation of vasoconstriction
GO:0046928 regulation of neurotransmitter secretion
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Ca2+ activated K+ channels pathway
Neuronal System pathway
cGMP effects pathway
Platelet homeostasis pathway
Potassium Channels pathway
Hemostasis pathway
Nitric oxide stimulates guanylate cyclase pathway
KEGG
Vascular smooth muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.525529 Hs.598920
RefSeq NM_014505
HUGO
OMIM
CCDS CCDS8997
HPRD 05564
IMGT
EMBL
GenPept
RNA Seq Atlas