Version 5.4
Homo sapiens Protein: KCNMB4
Summary
InnateDB Protein IDBP-47626.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNMB4
Protein Name potassium large conductance calcium-activated channel, subfamily M, beta member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258111
InnateDB Gene IDBG-47624 (KCNMB4)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269PubMed:10692449, ECO:0000269PubMed:10792058, ECO:0000269PubMed:10828459}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues. {ECO:0000269PubMed:10692449, ECO:0000269PubMed:10828459}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
Biological Process
GO:0001508 action potential
GO:0005513 detection of calcium ion
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0019228 neuronal action potential
GO:0019229 regulation of vasoconstriction
GO:0046928 regulation of neurotransmitter secretion
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003930 Potassium channel, calcium-activated, BK, beta subunit
PFAM PF03185
PRINTS PR01450
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86W47
PhosphoSite PhosphoSite-Q86W47
TrEMBL
UniProt Splice Variant
Entrez Gene 27345
UniGene Hs.598920
RefSeq NP_055320
HUGO HGNC:6289
OMIM 605223
CCDS CCDS8997
HPRD 05564
IMGT
EMBL AF160967 AF170917 AF207992 AF215891 BC042446 BC050621
GenPept AAF28333 AAF69805 AAF75596 AAF89699 AAH42446 AAH50621

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca