InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC23A1

Summary

InnateDB Gene

IDBG-47666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC23A1

Gene Name

solute carrier family 23 (nucleobase transporters), member 1

Synonyms

SLC23A2; SVCT1; YSPL3

Species

Homo sapiens

Ensembl Gene

ENSG00000170482

Encoded Proteins

IDBP-47668

solute carrier family 23 (nucleobase transporters), member 1

IDBP-47670

solute carrier family 23 (nucleobase transporters), member 1

IDBP-478635

solute carrier family 23 (nucleobase transporters), member 1

IDBP-476230

solute carrier family 23 (nucleobase transporters), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:139367196-139384553

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000353963	ENSP00000302851
ENST00000348729	ENSP00000302701
ENST00000504513	ENSP00000422688
ENST00000506512
ENST00000503919
ENST00000502863
ENST00000508270	ENSP00000427271

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008520	L-ascorbate:sodium symporter activity
GO:0015081	sodium ion transmembrane transporter activity
GO:0015205	nucleobase transmembrane transporter activity
GO:0015229	L-ascorbic acid transporter activity
GO:0033300	dehydroascorbic acid transporter activity
GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0006814	sodium ion transport
GO:0007420	brain development
GO:0009636	response to toxic substance
GO:0015851	nucleobase transport
GO:0015882	L-ascorbic acid transport
GO:0019852	L-ascorbic acid metabolic process
GO:0030324	lung development
GO:0035461	vitamin transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0070837	dehydroascorbic acid transport
GO:0070904	transepithelial L-ascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0043229	intracellular organelle
GO:0070062	extracellular vesicular exosome