InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC23A1

Summary

InnateDB Protein

IDBP-47670.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC23A1

Protein Name

solute carrier family 23 (nucleobase transporters), member 1

Synonyms

SLC23A2; SVCT1; YSPL3;

Species

Homo sapiens

Ensembl Protein

ENSP00000302701

InnateDB Gene

IDBG-47666 (SLC23A1)

Protein Structure

UniProt Annotation

Function

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19379732}; Multi-pass membrane protein {ECO:0000269PubMed:19379732}.

Disease Associations

Tissue Specificity

Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008520	L-ascorbate:sodium symporter activity
GO:0015081	sodium ion transmembrane transporter activity
GO:0015205	nucleobase transmembrane transporter activity
GO:0015229	L-ascorbic acid transporter activity
GO:0033300	dehydroascorbic acid transporter activity
GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0006814	sodium ion transport
GO:0007420	brain development
GO:0009636	response to toxic substance
GO:0015851	nucleobase transport
GO:0015882	L-ascorbic acid transport
GO:0019852	L-ascorbic acid metabolic process
GO:0035461	vitamin transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0070837	dehydroascorbic acid transport
GO:0070904	transepithelial L-ascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0043229	intracellular organelle
GO:0070062	extracellular vesicular exosome