InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NRG2

Summary

InnateDB Gene

IDBG-48049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRG2

Gene Name

neuregulin 2

Synonyms

DON1; HRG2; NTAK

Species

Homo sapiens

Ensembl Gene

ENSG00000158458

Encoded Proteins

IDBP-48051

neuregulin 2

IDBP-48053

neuregulin 2

IDBP-48055

neuregulin 2

IDBP-48057

neuregulin 2

IDBP-48059

neuregulin 2

IDBP-48063

neuregulin 2

IDBP-602498

neuregulin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:139846779-140043299

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000289422	ENSP00000289422
ENST00000358522	ENSP00000351323
ENST00000361474	ENSP00000354910
ENST00000289409	ENSP00000289409
ENST00000340391	ENSP00000342660
ENST00000378238	ENSP00000367483
ENST00000519478
ENST00000518130
ENST00000541337	ENSP00000444235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009790	embryo development
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling