Homo sapiens Gene: NRG2
Summary
InnateDB Gene IDBG-48049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRG2
Gene Name neuregulin 2
Synonyms DON1; HRG2; NTAK;
Species Homo sapiens
Ensembl Gene ENSG00000158458
Encoded Proteins
neuregulin 2
neuregulin 2
neuregulin 2
neuregulin 2
neuregulin 2
neuregulin 2
neuregulin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:139846779-140043299
Strand Reverse strand
Band q31.2
Transcripts
ENST00000289422 ENSP00000289422
ENST00000358522 ENSP00000351323
ENST00000361474 ENSP00000354910
ENST00000289409 ENSP00000289409
ENST00000340391 ENSP00000342660
ENST00000378238 ENSP00000367483
ENST00000519478
ENST00000518130
ENST00000541337 ENSP00000444235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009790 embryo development
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
GRB2 events in ERBB2 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
SHC1 events in ERBB2 signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Nuclear signaling by ERBB4 pathway
GRB7 events in ERBB2 signaling pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
ErbB signaling pathway pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Neuroregulin receptor degredation protein-1 controls erbb3 receptor recycling [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
G-secretase mediated erbb4 signaling pathway [Biocarta view]
PID NCI
ErbB4 signaling events
ErbB2/ErbB3 signaling events
ErbB receptor signaling network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.408515
RefSeq NM_001184935 NM_004883 NM_013981 NM_013982 NM_013983 XM_005268533 XM_006714809
HUGO
OMIM
CCDS CCDS4217 CCDS54910
HPRD 04821
IMGT
EMBL
GenPept
RNA Seq Atlas