Bos taurus Gene: NRG2
InnateDB Gene IDBG-646032.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRG2
Gene Name Uncharacterized protein
Species Bos taurus
Ensembl Gene ENSBTAG00000010689
Encoded Proteins
neuregulin 2
neuregulin 2
neuregulin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158458:
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:52714639-52774754
Strand Reverse strand
ENSBTAT00000065759 ENSBTAP00000055526
ENSBTAT00000014144 ENSBTAP00000014144
ENSBTAT00000063968 ENSBTAP00000055326
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0009790 embryo development
Cellular Component
Homo sapiens
Mus musculus
Gene ID
Gene Order
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
GRB2 events in ERBB2 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
SHC1 events in ERBB2 signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Nuclear signaling by ERBB4 pathway
GRB7 events in ERBB2 signaling pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
ErbB signaling pathway pathway
ErbB signaling pathway pathway
GPCR signaling pathway
Neuroregulin receptor degredation protein-1 controls erbb3 receptor recycling [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
G-secretase mediated erbb4 signaling pathway [Biocarta view]
ErbB4 signaling events
ErbB2/ErbB3 signaling events
ErbB receptor signaling network
UniProt Splice Variant
Entrez Gene
UniGene Bt.41146
RefSeq XM_003586310
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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