|Homo sapiens Gene: IL33|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 33|
|Useful resources||Stemformatics EHFPI ImmGen|
IL33, a member of the IL-1-related cytokines, is the first factor shown to modulate tryptase expression in mast cells (MCs). Synovial fibroblasts promote the expression and granule accumulation of tryptase via IL33 and its receptor ST-2 (IL1RL1).
IL33 attenuates sepsis by enhancing neutrophil influx to the site of infection by preventing the down-regulation of CXCR2 and reverses the TLR4-induced reduction of CXCR2 expression in neutrophils via the inhibition of expression of G protein-coupled receptor kinase-2 (GRK2).
IL33 is a crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses, where it is essential for manifestation of T cell-independent protease allergen-induced airway inflammation as well as OVA-induced allergic topical airway inflammation, without affecting acquisition of antigen-specific memory T cells.
IL33 is produced in alveolar macrophages that have been infected with Influenza A virus. The IL33-IL13 signalling axis is required for airway hyper-reactivity in asthma. (Demonstrated in murine model)
Innate lymphoid cells responding to IL33 mediate airway hyperreactivity independently of adaptive immunity. (Demonstrated in mice)
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]
|Genomic Location||Chromosome 9:6215786-6257983|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
Cytosolic DNA-sensing pathway pathway
|UniProt Splice Variant|
|RefSeq||NM_001199640 NM_001199641 NM_033439 XM_005251626 XM_005251627|
|CCDS||CCDS56563 CCDS56564 CCDS6468|
|EMBL||AB024518 AK295908 AK303943 AK313414 AL353741 AY905581 BC047085 CH471071 CR407619 HQ641439|
|GenPept||AAH47085 AAX86998 ADR77828 BAA75892 BAG36208 BAG58697 BAG64871 CAG28547 CAI16003 EAW58748 EAW58750 EAW58751|
|RNA Seq Atlas||90865|