Homo sapiens Gene: IL33
Summary
InnateDB Gene IDBG-48350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL33
Gene Name interleukin 33
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137033
Encoded Proteins
interleukin 33
interleukin 33
interleukin 33
interleukin 33
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL33, a member of the IL-1-related cytokines, is the first factor shown to modulate tryptase expression in mast cells (MCs). Synovial fibroblasts promote the expression and granule accumulation of tryptase via IL33 and its receptor ST-2 (IL1RL1).
IL33 attenuates sepsis by enhancing neutrophil influx to the site of infection by preventing the down-regulation of CXCR2 and reverses the TLR4-induced reduction of CXCR2 expression in neutrophils via the inhibition of expression of G protein-coupled receptor kinase-2 (GRK2).
IL33 is a crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses, where it is essential for manifestation of T cell-independent protease allergen-induced airway inflammation as well as OVA-induced allergic topical airway inflammation, without affecting acquisition of antigen-specific memory T cells.
IL33 is produced in alveolar macrophages that have been infected with Influenza A virus. The IL33-IL13 signalling axis is required for airway hyper-reactivity in asthma. (Demonstrated in murine model)
Innate lymphoid cells responding to IL33 mediate airway hyperreactivity independently of adaptive immunity. (Demonstrated in mice)
Entrez Gene
Summary IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:6215786-6257983
Strand Forward strand
Band p24.1
Transcripts
ENST00000381434 ENSP00000370842
ENST00000456383 ENSP00000414238
ENST00000417746 ENSP00000394039
ENST00000463336
ENST00000611532 ENSP00000478858
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0002686 negative regulation of leukocyte migration
GO:0002826 negative regulation of T-helper 1 type immune response
GO:0002830 positive regulation of type 2 immune response
GO:0006351 transcription, DNA-templated
GO:0010628 positive regulation of gene expression
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032689 negative regulation of interferon-gamma production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032755 positive regulation of interleukin-6 production
GO:0043032 positive regulation of macrophage activation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050729 positive regulation of inflammatory response
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051025 negative regulation of immunoglobulin secretion
GO:0090197 positive regulation of chemokine secretion
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030133 transport vesicle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Cytosolic DNA-sensing pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95760
TrEMBL
UniProt Splice Variant
Entrez Gene 90865
UniGene Hs.614903 Hs.731660
RefSeq NM_001199640 NM_001199641 NM_033439 XM_005251626 XM_005251627
HUGO HGNC:16028
OMIM 608678
CCDS CCDS56563 CCDS56564 CCDS6468
HPRD
IMGT
EMBL AB024518 AK295908 AK303943 AK313414 AL353741 AY905581 BC047085 CH471071 CR407619 HQ641439
GenPept AAH47085 AAX86998 ADR77828 BAA75892 BAG36208 BAG58697 BAG64871 CAG28547 CAI16003 EAW58748 EAW58750 EAW58751
RNA Seq Atlas 90865