Homo sapiens Gene: TUBB3
Summary
InnateDB Gene IDBG-48628.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUBB3
Gene Name tubulin, beta 3 class III
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198211
Encoded Proteins
Melanocyte-stimulating hormone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:89919165-89936092
Strand Forward strand
Band q24.3
Transcripts
ENST00000556922 ENSP00000451560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004930 G-protein coupled receptor activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007017 microtubule-based process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0051258 protein polymerization
Cellular Component
GO:0005874 microtubule
GO:0016021 integral component of membrane
GO:0043234 protein complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Phagosome pathway
Gap junction pathway
Pathogenic Escherichia coli infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL G3V2A3 G3V542 Q3ZCR3 Q9BV28 V9Q8F1
UniProt Splice Variant
Entrez Gene 10381
UniGene
RefSeq
HUGO HGNC:20772
OMIM 602661
CCDS
HPRD 04044
IMGT
EMBL AC092143 BC001678 BC047518 KC982213
GenPept AAH01678 AAH47518 AHC09974
RNA Seq Atlas 10381