InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GIF

Summary

InnateDB Gene

IDBG-48675.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GIF

Gene Name

gastric intrinsic factor (vitamin B synthesis)

Synonyms

IF; IFMH; INF; TCN3

Species

Homo sapiens

Ensembl Gene

ENSG00000134812

Encoded Proteins

IDBP-48677

gastric intrinsic factor (vitamin B synthesis)

IDBP-584635

gastric intrinsic factor (vitamin B synthesis)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:59829268-59845501

Strand

Reverse strand

Band

q12.1

Transcripts

ENST00000257248	ENSP00000257248
ENST00000525058	ENSP00000433196
ENST00000533067
ENST00000533847
ENST00000532070

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031419	cobalamin binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006824	cobalt ion transport
GO:0009235	cobalamin metabolic process
GO:0015889	cobalamin transport
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005768	endosome
GO:0005902	microvillus
GO:0016324	apical plasma membrane
GO:0043202	lysosomal lumen