InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GIF

Summary

InnateDB Protein

IDBP-48677.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GIF

Protein Name

gastric intrinsic factor (vitamin B synthesis)

Synonyms

IF; IFMH; INF; TCN3;

Species

Homo sapiens

Ensembl Protein

ENSP00000257248

InnateDB Gene

IDBG-48675 (GIF)

Protein Structure

UniProt Annotation

Function

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.

Subcellular Localization

Secreted.

Disease Associations

Hereditary intrinsic factor deficiency (IFD) [MIM:261000]: Autosomal recessive disorder characterized by megaloblastic anemia. {ECO:0000269PubMed:15738392}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Gastric mucosa.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031419	cobalamin binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006824	cobalt ion transport
GO:0009235	cobalamin metabolic process
GO:0015889	cobalamin transport
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005768	endosome
GO:0005902	microvillus
GO:0016324	apical plasma membrane
GO:0043202	lysosomal lumen