Version 5.4
Homo sapiens Gene: KRT19
Summary
InnateDB Gene IDBG-49363.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT19
Gene Name keratin 19
Synonyms CK19; K19; K1CS
Species Homo sapiens
Ensembl Gene ENSG00000171345
Encoded Proteins
IDBP-49365
keratin 19
IDBP-378133
keratin 19
IDBP-759129
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:41523617-41528308
Strand Reverse strand
Band q21.2
Transcripts
ENST00000361566 ENSP00000355124
ENST00000455635 ENSP00000408759
ENST00000468880
ENST00000471565
ENST00000479031
ENST00000462611
ENST00000593096 ENSP00000466625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0032403 protein complex binding
Biological Process
GO:0016032 viral process
GO:0043627 response to estrogen
GO:0045214 sarcomere organization
GO:0060706 cell differentiation involved in embryonic placenta development
Cellular Component
GO:0005882 intermediate filament
GO:0016010 dystrophin-associated glycoprotein complex
GO:0030018 Z disc
GO:0042383 sarcolemma
GO:0043034 costamere
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020911
View Gene Order
ENSBTAG00000004905
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL C9JM50
UniProt Splice Variant
Entrez Gene 3880
UniGene
RefSeq NM_002276
HUGO HGNC:6436
OMIM 148020
CCDS CCDS11399
HPRD 01007
IMGT
EMBL AC019349
GenPept
RNA Seq Atlas 3880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca