Homo sapiens Gene: PAWR
Summary
InnateDB Gene IDBG-49368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAWR
Gene Name PRKC, apoptosis, WT1, regulator
Synonyms Par-4; PAR4;
Species Homo sapiens
Ensembl Gene ENSG00000177425
Encoded Proteins
PRKC, apoptosis, WT1, regulator
PRKC, apoptosis, WT1, regulator
PRKC, apoptosis, WT1, regulator
PRKC, apoptosis, WT1, regulator
PRKC, apoptosis, WT1, regulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:79574979-79691097
Strand Reverse strand
Band q21.2
Transcripts
ENST00000328827 ENSP00000328088
ENST00000548075
ENST00000550603 ENSP00000447507
ENST00000549050
ENST00000547699
ENST00000551712 ENSP00000448317
ENST00000550006
ENST00000547571
ENST00000547016
ENST00000548426 ENSP00000447454
ENST00000552637 ENSP00000449928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 53 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0043522 leucine zipper domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0030889 negative regulation of B cell proliferation
GO:0042094 interleukin-2 biosynthetic process
GO:0042130 negative regulation of T cell proliferation
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051017 actin filament bundle assembly
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005884 actin filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Ceramide signaling pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL H0YHP5
UniProt Splice Variant
Entrez Gene 5074
UniGene Hs.600405 Hs.602479 Hs.635425 Hs.643130 Hs.687319 Hs.733764
RefSeq NM_002583 XM_006719435
HUGO HGNC:8614
OMIM 601936
CCDS CCDS31863
HPRD 09051
IMGT
EMBL AC027288 AC073569 AC073595
GenPept
RNA Seq Atlas 5074