Version 5.4
Homo sapiens Gene: PAWR
Summary
InnateDB Gene IDBG-49368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAWR
Gene Name PRKC, apoptosis, WT1, regulator
Synonyms Par-4; PAR4
Species Homo sapiens
Ensembl Gene ENSG00000177425
Encoded Proteins
IDBP-49370
PRKC, apoptosis, WT1, regulator
IDBP-594641
PRKC, apoptosis, WT1, regulator
IDBP-594655
PRKC, apoptosis, WT1, regulator
IDBP-599971
PRKC, apoptosis, WT1, regulator
IDBP-584055
PRKC, apoptosis, WT1, regulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:79574979-79691097
Strand Reverse strand
Band q21.2
Transcripts
ENST00000328827 ENSP00000328088
ENST00000548075
ENST00000550603 ENSP00000447507
ENST00000549050
ENST00000547699
ENST00000551712 ENSP00000448317
ENST00000550006
ENST00000547571
ENST00000547016
ENST00000548426 ENSP00000447454
ENST00000552637 ENSP00000449928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 53 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0043522 leucine zipper domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0030889 negative regulation of B cell proliferation
GO:0042094 interleukin-2 biosynthetic process
GO:0042130 negative regulation of T cell proliferation
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051017 actin filament bundle assembly
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005884 actin filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035873
View Gene Order
ENSBTAG00000043949
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.600405 Hs.602479 Hs.635425 Hs.643130 Hs.687319 Hs.733764
RefSeq NM_002583 XM_006719435
HUGO
OMIM
CCDS CCDS31863
HPRD 09051
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca