Homo sapiens Gene: PTGDR2
Summary
InnateDB Gene IDBG-49374.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGDR2
Gene Name prostaglandin D2 receptor 2
Synonyms CD294; CRTH2; DL1R; DP2; GPR44;
Species Homo sapiens
Ensembl Gene ENSG00000183134
Encoded Proteins
G protein-coupled receptor 44
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3\' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60850940-60855971
Strand Reverse strand
Band q12.2
Transcripts
ENST00000332539 ENSP00000332812
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001785 prostaglandin J receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004956 prostaglandin D receptor activity
GO:0004958 prostaglandin F receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0019722 calcium-mediated signaling
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eicosanoid ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
Prostanoid ligand receptors pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y5Y4
TrEMBL
UniProt Splice Variant
Entrez Gene 11251
UniGene Hs.299567
RefSeq NM_004778
HUGO HGNC:4502
OMIM 604837
CCDS CCDS7994
HPRD 16075
IMGT
EMBL AB008535 AF118265 AF144308 AP000777 AY507142 BC096841
GenPept AAD21055 AAD34539 AAH96841 AAR92484 BAA74518
RNA Seq Atlas 11251