Homo sapiens Gene: PTGDR2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-49374.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PTGDR2 | ||||||||||||||||||
Gene Name | prostaglandin D2 receptor 2 | ||||||||||||||||||
Synonyms | CD294; CRTH2; DL1R; DP2; GPR44 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000183134 | ||||||||||||||||||
Encoded Proteins |
G protein-coupled receptor 44
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011] This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3\' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 11:60850940-60855971 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q12.2 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
G alpha (i) signalling events pathway
Prostanoid ligand receptors pathway
Eicosanoid ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9Y5Y4 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 11251 | ||||||||||||||||||
UniGene | Hs.299567 | ||||||||||||||||||
RefSeq | NM_004778 | ||||||||||||||||||
HUGO | HGNC:4502 | ||||||||||||||||||
OMIM | 604837 | ||||||||||||||||||
CCDS | CCDS7994 | ||||||||||||||||||
HPRD | 16075 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB008535 AF118265 AF144308 AP000777 AY507142 BC096841 | ||||||||||||||||||
GenPept | AAD21055 AAD34539 AAH96841 AAR92484 BAA74518 | ||||||||||||||||||
RNA Seq Atlas | 11251 | ||||||||||||||||||