InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGDR2

Summary

InnateDB Protein

IDBP-49376.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGDR2

Protein Name

G protein-coupled receptor 44

Synonyms

CD294; CRTH2; DL1R; DP2; GPR44;

Species

Homo sapiens

Ensembl Protein

ENSP00000332812

InnateDB Gene

IDBG-49374 (PTGDR2)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269PubMed:11208866, ECO:0000269PubMed:11535533, ECO:0000269PubMed:17196174}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269PubMed:17207480}.

Disease Associations

Tissue Specificity

Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. {ECO:0000269PubMed:11168006, ECO:0000269PubMed:11208866, ECO:0000269PubMed:12466225, ECO:0000269PubMed:9973380}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001785	prostaglandin J receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004956	prostaglandin D receptor activity
GO:0004958	prostaglandin F receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0019722	calcium-mediated signaling
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway