Version 5.4
Homo sapiens Gene: HARS2
Summary
InnateDB Gene IDBG-49399.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HARS2
Gene Name histidyl-tRNA synthetase 2, mitochondrial
Synonyms HARSL; HARSR; HO3; PRLTS2
Species Homo sapiens
Ensembl Gene ENSG00000112855
Encoded Proteins
IDBP-49401
histidyl-tRNA synthetase 2, mitochondrial (putative)
IDBP-378721
histidyl-tRNA synthetase 2, mitochondrial (putative)
IDBP-482269
histidyl-tRNA synthetase 2, mitochondrial (putative)
IDBP-485248
histidyl-tRNA synthetase 2, mitochondrial (putative)
IDBP-480255
histidyl-tRNA synthetase 2, mitochondrial (putative)
IDBP-480709
histidyl-tRNA synthetase 2, mitochondrial (putative)
IDBP-482204
histidyl-tRNA synthetase 2, mitochondrial (putative)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter. [provided by RefSeq, Jul 2008]
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140691426-140699291
Strand Forward strand
Band q31.3
Transcripts
ENST00000230771 ENSP00000230771
ENST00000448069 ENSP00000407105
ENST00000520095 ENSP00000429220
ENST00000510104 ENSP00000423530
ENST00000509299 ENSP00000425695
ENST00000511913
ENST00000503873 ENSP00000424516
ENST00000502303
ENST00000513912
ENST00000506318
ENST00000508522 ENSP00000423616
ENST00000513688
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006427 histidyl-tRNA aminoacylation
GO:0008152 metabolic process
GO:0010467 gene expression
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019143
View Gene Order
ENSBTAG00000025212
Not yet available
Pathways
NETPATH
REACTOME
REACT_15302
Mitochondrial tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.432560
RefSeq NM_001278731 NM_012208 XM_006714777
HUGO
OMIM
CCDS CCDS4238 CCDS64267
HPRD 02871
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca