InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HARS2

Summary

InnateDB Protein

IDBP-49401.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HARS2

Protein Name

histidyl-tRNA synthetase 2, mitochondrial (putative)

Synonyms

HARSL; HARSR; HO3; PRLTS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000230771

InnateDB Gene

IDBG-49399 (HARS2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Perrault syndrome 2 (PRLTS2) [MIM:614926]: A sex- influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile. {ECO:0000269PubMed:21464306}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

A high level expression is seen in the heart, kidney and skeletal muscle while a lower level expression is seen in the brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004821	histidine-tRNA ligase activity
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006427	histidyl-tRNA aminoacylation
GO:0010467	gene expression

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
IPR004154 Anticodon-binding
IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR015807 Histidine-tRNA ligase

PFAM

PF00587
PF03129

PRINTS

PIRSF

PIRSF001549

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49590