Version 5.4
Homo sapiens Gene: ZP1
Summary
InnateDB Gene IDBG-49417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZP1
Gene Name zona pellucida glycoprotein 1 (sperm receptor)
Synonyms HEL163; OOMD
Species Homo sapiens
Ensembl Gene ENSG00000149506
Encoded Proteins
IDBP-49419
zona pellucida glycoprotein 1 (sperm receptor)
IDBP-603357
zona pellucida glycoprotein 1 (sperm receptor)
IDBP-810208
zona pellucida glycoprotein 1 (sperm receptor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60867562-60875693
Strand Forward strand
Band q12.2
Transcripts
ENST00000278853 ENSP00000278853
ENST00000540908 ENSP00000441293
ENST00000537203
ENST00000542971
ENST00000543020
ENST00000620319 ENSP00000480463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0032504 multicellular organism reproduction
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030141 secretory granule
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024734
View Gene Order
Pathways
NETPATH
REACTOME
REACT_163933
Interaction With The Zona Pellucida pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_207341
HUGO
OMIM
CCDS CCDS31572
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca