Homo sapiens Gene: HNRNPL
Summary
InnateDB Gene IDBG-49631.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPL
Gene Name heterogeneous nuclear ribonucleoprotein L
Synonyms hnRNP-L; HNRPL;
Species Homo sapiens
Ensembl Gene ENSG00000104824
Encoded Proteins
heterogeneous nuclear ribonucleoprotein L
heterogeneous nuclear ribonucleoprotein L
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
THRIL, a large intergenic noncoding RNA, binds to heterogenous nuclear ribonucleoprotein L (HNRNPL) and forms a functional THRIL-HNRNPL complex that regulates transcription of TNF by binding to its promoter.
Entrez Gene
Summary Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38836388-38852347
Strand Reverse strand
Band q13.2
Transcripts
ENST00000221419 ENSP00000221419
ENST00000388749 ENSP00000373401
ENST00000600873 ENSP00000470231
ENST00000601813 ENSP00000469913
ENST00000595443
ENST00000595164
ENST00000600741
ENST00000595804
ENST00000597731
ENST00000598985
ENST00000601664
ENST00000601449 ENSP00000469349
ENST00000601047
ENST00000600233 ENSP00000472150
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 93 [view]
Protein-Protein 91 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
GO:0045120 pronucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.644906 Hs.718661
RefSeq NM_001005335 NM_001533
HUGO
OMIM
CCDS CCDS33015 CCDS33016
HPRD 04360
IMGT
EMBL
GenPept
RNA Seq Atlas