InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RHEB

Summary

InnateDB Gene

IDBG-49648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHEB

Gene Name

Ras homolog enriched in brain

Synonyms

RHEB2

Species

Homo sapiens

Ensembl Gene

ENSG00000106615

Encoded Proteins

IDBP-49650

Ras homolog enriched in brain

IDBP-476639

Ras homolog enriched in brain

IDBP-474826

Ras homolog enriched in brain

IDBP-481151

Ras homolog enriched in brain

IDBP-480064

Ras homolog enriched in brain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24130493

[Mus musculus] Mycobacterial infection induces expression of Mir155, which promotes the maturation of phagosomes and represses the expression of Rheb by targeting its 3�??UTR

PMID 24282297

[Mus musculus] The interplay between Tsc1-Rheb-mTOR complex 1 signalling and Myc-dependent metabolism are dynamically regulated during dentritic cell (DC) development, whereas uncontrolled mTORC1 activation impairs DC development.

Entrez Gene

Summary

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:151466012-151520120

Strand

Reverse strand

Band

q36.1

Transcripts

ENST00000262187	ENSP00000262187
ENST00000472642	ENSP00000420726
ENST00000478470	ENSP00000417802
ENST00000496004	ENSP00000418161
ENST00000470072
ENST00000470370	ENSP00000417212
ENST00000482053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	52 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0015031	protein transport
GO:0032008	positive regulation of TOR signaling

Cellular Component

GO:0005622	intracellular
GO:0005681	spliceosomal complex
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome