Homo sapiens Gene: RHEB
Summary
InnateDB Gene IDBG-49648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHEB
Gene Name Ras homolog enriched in brain
Synonyms RHEB2
Species Homo sapiens
Ensembl Gene ENSG00000106615
Encoded Proteins
Ras homolog enriched in brain
Ras homolog enriched in brain
Ras homolog enriched in brain
Ras homolog enriched in brain
Ras homolog enriched in brain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Mycobacterial infection induces expression of Mir155, which promotes the maturation of phagosomes and represses the expression of Rheb by targeting its 3??UTR
[Mus musculus] The interplay between Tsc1-Rheb-mTOR complex 1 signalling and Myc-dependent metabolism are dynamically regulated during dentritic cell (DC) development, whereas uncontrolled mTORC1 activation impairs DC development.
Entrez Gene
Summary This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:151466012-151520120
Strand Reverse strand
Band q36.1
Transcripts
ENST00000262187 ENSP00000262187
ENST00000472642 ENSP00000420726
ENST00000478470 ENSP00000417802
ENST00000496004 ENSP00000418161
ENST00000470072
ENST00000470370 ENSP00000417212
ENST00000482053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 52 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0015031 protein transport
GO:0032008 positive regulation of TOR signaling
Cellular Component
GO:0005622 intracellular
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Release of eIF4E pathway
S6K1-mediated signalling pathway
Regulation of Rheb GTPase activity by AMPK pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
PKB-mediated events pathway
mTORC1-mediated signalling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IGF1R signaling cascade pathway
KEGG
mTOR signaling pathway pathway
Insulin signaling pathway pathway
INOH
Insulin receptor signaling pathway
PID NCI
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.594412 Hs.647068 Hs.737946
RefSeq NM_005614 XM_006716081
HUGO
OMIM
CCDS CCDS5927
HPRD 03188
IMGT
EMBL
GenPept
RNA Seq Atlas