Homo sapiens Gene: NTS
Summary
InnateDB Gene IDBG-50023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTS
Gene Name neurotensin
Synonyms NMN-125; NN; NT; NT/N; NTS1;
Species Homo sapiens
Ensembl Gene ENSG00000133636
Encoded Proteins
neurotensin
neurotensin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:85874295-85882992
Strand Forward strand
Band q21.31
Transcripts
ENST00000256010 ENSP00000256010
ENST00000551529 ENSP00000448328
ENST00000550879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0050880 regulation of blood vessel size
Cellular Component
GO:0005576 extracellular region
GO:0030133 transport vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
PID BIOCARTA
PID NCI
AP-1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006183
HUGO
OMIM
CCDS CCDS9029
HPRD 08878
IMGT
EMBL
GenPept
RNA Seq Atlas