Version 5.4
Homo sapiens Gene: XRCC2
Summary
InnateDB Gene IDBG-50037.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRCC2
Gene Name X-ray repair complementing defective repair in Chinese hamster cells 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196584
Encoded Proteins
IDBP-50039
X-ray repair complementing defective repair in Chinese hamster cells 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:152644779-152676165
Strand Reverse strand
Band q36.1
Transcripts
ENST00000359321 ENSP00000352271
ENST00000495707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000724 double-strand break repair via homologous recombination
GO:0001701 in utero embryonic development
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007126 meiotic nuclear division
GO:0010165 response to X-ray
GO:0010332 response to gamma radiation
GO:0042148 strand invasion
GO:0043524 negative regulation of neuron apoptotic process
GO:0050769 positive regulation of neurogenesis
GO:0051297 centrosome organization
Cellular Component
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028933
View Gene Order
ENSBTAG00000030897
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt O43543
TrEMBL
UniProt Splice Variant
Entrez Gene 7516
UniGene Hs.647093
RefSeq NM_005431
HUGO HGNC:12829
OMIM 600375
CCDS CCDS5933
HPRD
IMGT
EMBL AC003109 AF035587 AF520762 AK313607 BC042137 CH471173 Y08837 Y17033
GenPept AAC05369 AAC05802 AAH42137 AAM55241 BAG36372 CAA70065 CAA76597 EAW53968
RNA Seq Atlas 102724498 7516

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca