Homo sapiens Gene: XRCC2
Summary
InnateDB Gene IDBG-50037.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRCC2
Gene Name X-ray repair complementing defective repair in Chinese hamster cells 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196584
Encoded Proteins
X-ray repair complementing defective repair in Chinese hamster cells 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:152644779-152676165
Strand Reverse strand
Band q36.1
Transcripts
ENST00000359321 ENSP00000352271
ENST00000495707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000724 double-strand break repair via homologous recombination
GO:0001701 in utero embryonic development
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007126 meiotic nuclear division
GO:0010165 response to X-ray
GO:0010332 response to gamma radiation
GO:0042148 strand invasion
GO:0043524 negative regulation of neuron apoptotic process
GO:0050769 positive regulation of neurogenesis
GO:0051297 centrosome organization
Cellular Component
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.647093
RefSeq NM_005431
HUGO
OMIM
CCDS CCDS5933
HPRD 02656
IMGT
EMBL
GenPept
RNA Seq Atlas