InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XRCC2

Summary

InnateDB Protein

IDBP-50039.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRCC2

Protein Name

X-ray repair complementing defective repair in Chinese hamster cells 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352271

InnateDB Gene

IDBG-50037 (XRCC2)

Protein Structure

UniProt Annotation

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. {ECO:0000269PubMed:11751635, ECO:0000269PubMed:11834724, ECO:0000269PubMed:21276791, ECO:0000269PubMed:23149936}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:21276791}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000400	four-way junction DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000724	double-strand break repair via homologous recombination
GO:0001701	in utero embryonic development
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007126	meiotic nuclear division
GO:0010165	response to X-ray
GO:0010332	response to gamma radiation
GO:0042148	strand invasion
GO:0043524	negative regulation of neuron apoptotic process
GO:0050769	positive regulation of neurogenesis
GO:0051297	centrosome organization

Cellular Component

GO:0005657	replication fork
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex

Protein Structure and Domains

PDB ID

InterPro

IPR013632 DNA recombination and repair protein Rad51, C-terminal
IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF08423

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43543

PhosphoSite