Homo sapiens Gene: PCDHB14
Summary
InnateDB Gene IDBG-50224.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHB14
Gene Name protocadherin beta 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120327
Encoded Proteins
protocadherin beta 14
protocadherin beta 14
protocadherin beta 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141222932-141227759
Strand Forward strand
Band q31.3
Transcripts
ENST00000239449 ENSP00000239449
ENST00000515856 ENSP00000444518
ENST00000624896 ENSP00000485055
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007268 synaptic transmission
GO:0007416 synapse assembly
GO:0016339 calcium-dependent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9Y5E9
TrEMBL B4DPE2
UniProt Splice Variant
Entrez Gene 56122
UniGene
RefSeq NM_018934 NM_018930
HUGO HGNC:8685
OMIM 606340
CCDS CCDS4256 CCDS4252
HPRD 06958
IMGT
EMBL AC005752 AF152493 AF217744 AK298296 BC098144 BC099728
GenPept AAD43754 AAH98144 AAH99728 AAK51612 BAG60554
RNA Seq Atlas 56122