Homo sapiens Gene: PAF1
Summary
InnateDB Gene IDBG-50230.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAF1
Gene Name Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006712
Encoded Proteins
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39385852-39391195
Strand Reverse strand
Band q13.2
Transcripts
ENST00000221265 ENSP00000221265
ENST00000416728 ENSP00000396412
ENST00000598127
ENST00000595379 ENSP00000469742
ENST00000595564 ENSP00000468874
ENST00000597365
ENST00000595797
ENST00000598594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 70 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001711 endodermal cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006378 mRNA polyadenylation
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0019827 stem cell maintenance
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0016593 Cdc73/Paf1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F8W9Q2 M0QX35
UniProt Splice Variant
Entrez Gene 54623
UniGene Hs.466714
RefSeq NM_001256826 NM_019088
HUGO HGNC:25459
OMIM 610506
CCDS CCDS59387 CCDS12533
HPRD 10140
IMGT
EMBL AC005239 CH471126
GenPept EAW56883
RNA Seq Atlas 54623