Version 5.4
Homo sapiens Gene: PAF1
Summary
InnateDB Gene IDBG-50230.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAF1
Gene Name Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006712
Encoded Proteins
IDBP-50232
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
IDBP-379764
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
IDBP-763960
IDBP-763214
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39385852-39391195
Strand Reverse strand
Band q13.2
Transcripts
ENST00000221265 ENSP00000221265
ENST00000416728 ENSP00000396412
ENST00000598127
ENST00000595379 ENSP00000469742
ENST00000595564 ENSP00000468874
ENST00000597365
ENST00000595797
ENST00000598594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 70 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001711 endodermal cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006378 mRNA polyadenylation
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0019827 stem cell maintenance
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0016593 Cdc73/Paf1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003437
View Gene Order
ENSBTAG00000020428
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.466714
RefSeq NM_001256826 NM_019088
HUGO
OMIM
CCDS CCDS12533 CCDS59387
HPRD 10140
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca